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GENOMIC SEQUENCING

Bryce Olson was diagnosed with aggressive stage 4 prostate cancer. When the standard of care didn’t work, Bryce turned to genomic sequencing which allowed his doctors to identify specific molecular drivers of his disease and identify specific treatments and clinical trials that were a better fit for his specific cancer.

“The driver of my cancer was hidden in my DNA. I asked my doctors to ‘Sequence Me.’ The insights from genomic sequencing opened new doors and saved my life. Fight cancer differently with data.”

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Q&A

Read these frequently asked questions, download the battle card and build confidence to understand the science, open new doors, and overcome objections or pushback. Be empowered and get more personalized care.

Q. Am I contributing also to the greater good by doing this?

Absolutely! You are helping accelerate cancer research and drug development by doing this. Almost all of the companies that provide these tests partner with bio-pharma clients throughout each stage of drug research and development, from target discovery to commercial launch. We need to develop better drugs, faster. Broad testing of patients would make more data available to bio-pharma companies, accelerating the pace of research and the identification

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of more patients for clinical trials. Ultimately, that could lead to the development of more effective — and cheaper — targeted drugs. It’s a virtuous cycle. In the future, more patients who receive a genomic diagnostic test like this would have a greater choice of approved treatment options for their specific cancer. We need to accelerate the development of treatments that provide the optimal outcome for every patient diagnosed with advanced cancer.

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Q. Do all the test results lead to actionable treatment options?

Foundation Medicine has reported on that. Of the 79,000 cancer patients FMI tested in 2017, 38% percent were matched with an FDA approved therapy, 83% percent were matched with at least one relevant clinical trial, and all of them had at least one of those two outcomes.

Q. What kind of results should I expect from these tests to help guide my care?

Each individual cancer is unique and test results vary depending on the tumor type. When applicable, test results may help identify the following insights.

1. New insights into the preferred ‘on-label’ standard of care therapies. This means therapies approved to treat your specific tumor type and shown to be effective in targeting one or more of the alterations found by

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the test.

2. New insights into off-label drugs: These are therapies approved in another tumor type (i.e. breast cancer) but possibly effective in targeting one or more of the genomic alterations found by the test that occur in your tumor (i.e. prostate cancer.)

3. A clinical trial evaluating therapies under development which may work by targeting an alteration found by the test that is in your tumor.

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Q. Regarding clinical trials, are there good trusted sources out there for me to find the right clinical trial “match” based on having genomic sequencing results?

There’s new innovation going on in this space. Most of the commercial diagnostic test companies listed earlier will offer clinical trial matching as part of their report back to patients and doctors. Other good sources include ClinicalTrials.gov, which is a database of privately and publicly funded clinical studies conducted around the world (though a little challenging to use), Massive Bio that uses artificial intelligence to help match you to clinical trials that cater

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to your specific cancer type and situation, and Cancer Research Institute that offers a Clinical Trial Finder to aid you in finding the answer to your cancer. As new innovation emerges, we’ll share it with you here.

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Q. Isn’t this just for the top 1% of patients with financial means?

No. Anybody with advanced cancer can demand and receive this. If your insurance doesn’t cover it, ask for financial assistance from the place doing the test.

Q. Isn’t there a risk that this will accelerate the adoption of drugs that aren’t ready and aren’t safe yet?

This isn’t a trade-off between speed and safety. This is about getting medicines designed specifically for patients who express biological characteristics (biomarkers) that increase the odds that a treatment will actually work for them. FDA is streamlining approvals for these treatments and personalized medicine can arguably have better safety and efficacy profiles than one-size fits all medicine of today.

Disclaimer: SequenceMe.org provides this information as a service. This information and material is strictly for educational purposes only and is not intended as medical advice, is not intended to take the place of medical professionals, or the recommendations of your healthcare team for prevention, diagnosis and treatment of medical issues. We strongly suggest consulting your healthcare team if you have questions about your specific care.

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07
Dec 2018

Genomic Sequencing: Precision data to better fight advanced cancer

Bryce Olson was recently featured on KATU Channel 2 News in Portland, Oregon. Watch Bryce’s story and learn how gene testing helped Bryce. “The message I just really want to deliver is: demand sequencing. Demand genomic sequencing.”

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18
Nov 2018

From standard to personalised cancer care

The walls of Foundation Medicine’s lounge are filled with photographs of patients who have benefited from the power of genomic profiling to alter the course…

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31
Oct 2018

Precision medicine means nobody is just ‘average’

The rise in precision medicine, fueled by next-generation sequencing tests and increasingly by liquid biopsy as well, has given rise to treatments targeted not to…

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05
Apr 2018

Raising Awareness About Precision Medicine. ‘Sequence Me’

Bryce Olson orchestrated his own treatment by assembling a team of scientists, requesting to have his genome sequenced and seeking out targeted therapies. READ this informative…

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