Feb 2019

Q. How does genomic testing differ from genetic testing?

By boadmin11

Genetic testing detects hereditary (inherited from parents) alterations in DNA while genomic testing detects acquired (over the course of a lifetime) alterations in DNA. Acquired alterations are responsible for the majority of cancers and may impact tumor growth, spread, and response to therapy. Comprehensive genomic profiling (CGP) is far superior to single-gene testing that only identifies one or two classes of genomic alterations. CGP’s approach identifies

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four classes of genomic alterations: base substitutions, insertions and deletions/indels, copy number alterations, and rearrangements. The reason why a CGP is far superior to a single marker test is this: When you only look at just 1-2 things you run the risk of missing the actual targets that were causing the disease. Cancer is an incredibly complex disease and it’s crazy to presuppose that the smartest doctor can look at a specific patient and know the genes of interest. Unlike the standard single marker test — which assumes the site of a cancer’s origin, and looks for a specific genetic alteration — most comprehensive genomic sequencing tests do not presuppose knowledge of the cancer’s exact profile, and just look at everything.

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